Target
Human IL17RA
Synonyms
IL17RA | CANDF5 | CD217 antigen | CDw217 | CD217 | HIL-17R | IL-17RA | IL17R | Interleukin-17 receptor A | IL-17 receptor | IL-17 receptor A | Interleukin 17 receptor | Interleukin 17 receptor A
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated.
Also available conjugated with
HRP,
FITC,
Biotin.
Immunogen
Recombinant Human Interleukin-17 receptor A protein (552-743AA)
Specificity
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).