Target
Human GPX4 / MCSP
Synonyms
GPX4 | GPx-4 | MCSP | SnPHGPx | Phospholipid hydroperoxidase | SnGPx | Glutathione peroxidase 4 | GSHPx-4 | PHGPx
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant Human Phospholipid hydroperoxide glutathione peroxidase, mitochondrial protein (74-197AA)
Specificity
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.