Target
Human DNAJB6
Synonyms
DNAJB6 | DnaJ-like 2 protein | HSJ2 | LGMD1E | MRJ | MSJ-1 | MSJ1 | DJ4 | DnaJ | Heat shock protein J2 | HHDJ1 | HSJ-2
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant Human DnaJ homolog subfamily B member 6 protein (208-326AA)
Specificity
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.