Target
Human CTLA4 / CD152
Synonyms
CTLA4 | CD152 | CELIAC3 | CD152 antigen | CTLA-4 | Celiac disease 3 | IDDM12 | GRD4 | GSE | CD152 isoform
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Monoclonal
Conjugations
Unconjugated
Purification
Gel filtration
Modifications
Fab.
Also available
Unmodified or
Fab'2,
Azide-free.
Immunogen
Stimulated human PBL’s and human CD152 Ig fusion protein.
Specificity
CTLA-4 expressed on activated T cells.
Applications
- Flow Cytometry
- ELISA
- Functional Assay
Usage
Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Presentation
Sterile Solution 50 mM Sodium Phosphate, pH 7.5, 150 mM NaCl, 100 mM KCl, No preservatives added
Storage
Store at 4°C. Do not freeze. Open under aseptic conditions.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee