Target
Guinea pig Complement C3c
Reactivity
Guinea pig
(tested or 100% immunogen sequence identity)
Immunogen
C3c isolated and purified from pooled normal guinea pig serum
Specificity
Guinea pig C3c. In immunoelectrophoresis against fresh guinea pig serum, a single precipitin line is obtained in the beta-1 region representing native C3. Against serum containing partly activated C3, a precipitin line is obtained which extends from the beta-1 into the alpha-2 region, demonstrating a gradient. In old serum containing totally activated C3 a single precipitin line in the alpha-2 region is obtained. Also reacts with the fragments C3b, C3bi and smaller fragments, since they all carry antigenic determinants of the C3c domain. Does not react with any other proteins component of mouse serum or plasma.