Target
Human CD177
Synonyms
CD177 | CD177 molecule | CD177 antigen | Cell surface receptor | HNA-2a | HNA2A | NB1 | PRV-1 | Polycythemia rubra vera 1 | PRV1 | NB1 glycoprotein | NB1 GP
Reactivity
Human
(tested or 100% immunogen sequence identity)
Specificity
Cd177 (NP1), a glycosyl phosphatidylinositol (GPI) linked N glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia and analyses showed cell surface expression of a 60 kD protein, 14 kD greater than the predicted size, probably due to the presence of 3 potential N glycosylation sites. Immunohistochemistry demonstrated expression in bone marrow early erythroblasts, megakaryocytes, promyelocytes, and myelocytes. The neutrophil NB1 antigen (CD177) is expressed by 97% of the Caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN).