Target
Pig CD163
Synonyms
CD163 | CD163 antigen | Macrophage-associated antigen | M130 | CD163 molecule | Hemoglobin scavenger receptor | MM130
Reactivity
Pig
(tested or 100% immunogen sequence identity)
Immunogen
Porcine alveolar macrophages.
Specificity
Recognizes porcine CD163, a 120kD cell surface glycoprotein that is expressed on cells of the monocyte/macrophage lineage. The expression levels of CD163 vary during the course of macrophage differentiation. The highest levels of CD163 expression are found on tissue macrophages but bone marrow derived cells are CD163 negative. Expression of CD163 on peripheral blood monocytes varies between about 5% and 50% depending on the donor. Clone is reported to inhibit both African swine fever infection and viral particle binding to alveolar macrophages in a dose-dependent manner.