Target
Human C5AR1 / CD88 / C5a Receptor
Synonyms
C5AR1 | C5A | C5a-R | C5a ligand | C5a receptor | CD88 | C5a anaphylatoxin receptor | C5AR | C5R1 | CD88 antigen
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant human C5a anaphylatoxin chemotactic receptor 1 protein (1-36AA)
Specificity
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).