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ARID1A / BAF250
AT rich interactive domain 1A (SWI-like)
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
| Gene Name: | AT rich interactive domain 1A (SWI-like) |
| Synonyms: | ARID1A, BAF250, BAF250a, BRG1-associated factor 250a, C1orf4, BRG1-associated factor 250, ELD, HOSA1, Osa homolog 1, OSA1, OSA1 nuclear protein, SMARCF1, MRD14, p270, B120, BM029, Brain protein 120, C10rf4, HELD, SWI-like protein, SWI/SNF complex protein p270 |
| Target Sequences: | NM_006015 NP_006006.3 O14497 |
Publications (1)
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