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| Catalog Number | Size | Price |
|---|---|---|
| LS-C391824-7 | 7 ml | $574 |
Monoclonal Mouse anti‑Human ANO1 / DOG1 / TMEM16A Antibody (clone tDAN4, Ready‑to‑Use, IHC) LS‑C391824
Monoclonal Mouse anti‑Human ANO1 / DOG1 / TMEM16A Antibody (clone tDAN4, Ready‑to‑Use, IHC) LS‑C391824
Antibody:
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (Ready-to-Use) (tDAN4) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Ready-to-Use
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (Ready-to-Use) (tDAN4) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Ready-to-Use
Other formats:
Specifications
Description
TMEM16A antibody LS-C391824 is an unconjugated mouse monoclonal antibody to human TMEM16A (ANO1 / DOG1). Validated for IHC.
Target
Human ANO1 / DOG1 / TMEM16A
Synonyms
ANO1 | Oral cancer overexpressed 2 | Transmembrane protein 16A | ORAOV2 | Anoctamin-1 | DOG1 | TAOS2 | TMEM16A
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Monoclonal
Clone
tDAN4
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Ready-to-Use.
Also available Unmodified or Azide-free, BSA-free.
Immunogen
Recombinant human protein.
Specificity
Human ANO1 / DOG1 / TMEM16A
Applications
- IHC - Paraffin (1:1)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Expression of TMEM16A (DOG1) protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. It is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG11 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
Presentation
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ANO1 / DOG1 / TMEM16A
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, Western blot, ELISA
Species:
Human
Applications:
Western blot
Species:
Human, Monkey
Applications:
Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/27/2024
Date Requested: 12/27/2024
