Target
Human ADGRE2 / EMR2
Synonyms
ADGRE2 | CD312 antigen | EMR2 | EGF-like module receptor 2 | CD312
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
R. Phycoerythrin.
Also available
Unconjugated.
Immunogen
NIH-3T3 cells stably transfected with EMR2 (EGF1-5) cDNA.
Specificity
Recognizes human EMR2, a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family of proteins, which is closely related to CD97. EMR2, also known as CD312, is predominantly expressed on myeloid dendritic cells, monocytes and tissue macrophages. Various isoforms of EMR2 have been documented. The ligand for the largest isoform of EMR2 has recently been identified as chrondroitin sulphate, which binds to the fourth EGF-like module of EMR2. Clone 2A1 specifically recognizes the stalk region of EMR2.