ADGRE2 (EMR2, CD312, EGF-like module containing, mucin-like, hormone receptor-like 2) is a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. ADGRE2 is characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. ADGRE2 is situated in a cluster of related genes on chromosome 19. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804