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Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.
Gene Name: | zw10 kinetochore protein |
Synonyms: | ZW10, HZW10, KNTC1AP, Zeste white 10 homolog, Zw10 kinetochore protein |
Target Sequences: | NM_004724 NP_004715.1 O43264 |
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