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Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
Gene Name: | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 |
Synonyms: | ZRSR2, U2AF1RS2, U2AF35-related protein, U2AF1-RS2, U2AF1L2, URP |
Target Sequences: | NM_005089 NP_005080.1 Q15696 |
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