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ZNF280B is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.
Gene Name: | zinc finger protein 280B |
Family/Subfamily: | Zinc Finger |
Synonyms: | ZNF280B, 5OY11.1, 5'OY11.1, SUHW2, Zinc finger protein 279, ZNF632, Zinc finger protein 632, D87009.C22.3, Zinc finger protein 280B, ZNF279 |
Target Sequences: | Q86YH2 Q86YH2 |
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