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Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Gene Name: | zinc finger and BTB domain containing 18 |
Family/Subfamily: | Zinc Finger |
Synonyms: | ZBTB18, 58 kDa repressor protein, C2H2-171, RP58, Transcriptional repressor RP58, Zinc finger protein 238, Zinc finger protein C2H2-171, TAZ-1, TAZ1, ZNF238 |
Target Sequences: | NM_006352 NP_006343.2 Q99592 |
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