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ZMPSTE24
zinc metallopeptidase STE24
ZMPSTE24 is a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
| Gene Name: | zinc metallopeptidase STE24 |
| Family/Subfamily: | Protease , Metallopeptidase M48A |
| Synonyms: | ZMPSTE24, FACE1, FACE-1, HGPS, PRO1, Ste24p, Zinc metalloproteinase STE24, STE24, CAAX prenyl protease 1 homolog, MADB, Zinc metallopeptidase STE24 |
| Target Sequences: | NM_005857 NP_005848.2 O75844 |
Publications (3)
1
Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy. Moulson CL, Go G, Gardner JM, van der Wal AC, Smitt JH, van Hagen JM, Miner JH. The Journal of investigative dermatology. 2005 125:913-9.
[PubMed:16297189]
[PMC:PMC1360172]
Related Antibodies: LS-C99716.
2
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:13432-7.
[PubMed:17652517]
[PMC:PMC1948915]
3
Membrane proteins of human fetal primitive nucleated red blood cells. Ponnusamy S, Zhang H, Kadam P, Lin Q, Lim TK, Sandhu JS, Kothandaraman N, Mahyuddin AP, Biswas A, Venkat A, Hew CL, Joshi SB, Chung MC, Choolani M. Journal of proteomics. 2012 75:5762-73. (ICC; Human)
[PubMed:22842289]
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(33)
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Target
ZMPSTE24
(37)
Reactivity
Human
(34)
Mouse
(12)
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(4)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(3)
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(15)
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(2)
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(29)
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(23)
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(2)
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(1)
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rabbit
(32)
goat
(1)
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(28)
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polyclonal pc
(33)
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96-Well Strip Plate
(2)
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(3)
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(5)
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(5)
HRP Conjugated
(5)
PE Conjugated
(3)
Unconjugated
(12)
Epitope
aa400-430
(7)
aa404-433
(7)
aa440-470
(7)
aa83-132
(4)
aa400-475
(1)
aa464-475
(1)
Publications
No
(36)
Yes
(1)
Tag
GST
(1)
GST, N-terminus
(1)
Species
Human
(2)
Source
Wheat Germ Extract
(2)
Purification
Purified
(1)
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ZMPSTE24 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
ZMPSTE24 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$341
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa440-470) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-430) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
ZMPSTE24 Rabbit anti-Human Polyclonal (aa404-433) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
ZMPSTE24 Goat anti-Human Polyclonal (aa464-475) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
ZMPSTE24 Rabbit anti-Human Polyclonal (aa400-475) Antibody
Human
WB
Unconjugated
0.1 ml/$386
ZMPSTE24 Rabbit anti-Human Polyclonal (aa83-132) Antibody
Human
WB
Unconjugated
100 µl/$424
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