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ZIC4 is a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene.
Gene Name: | Zic family member 4 |
Synonyms: | ZIC4, Zic family member 4, Zinc finger protein ZIC 4 |
Target Sequences: | NM_032153 NP_115529.2 Q8N9L1 |
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