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This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene.
Gene Name: | zinc finger, FYVE domain containing 9 |
Family/Subfamily: | Zinc Finger |
Synonyms: | ZFYVE9, HSARA, Madh-interacting protein, Receptor activation anchor, SMADIP, MADHIP, Novel serine protease, NSP, SARA |
Target Sequences: | NM_004799 NP_004790.2 O95405 |
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