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Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Gene Name: | zinc finger E-box binding homeobox 1 |
Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
Synonyms: | ZEB1, AREB6, BZP, FECD6, NIL-2-A zinc finger protein, TCF-8, Negative regulator of IL2, NIL2A, ZEB, ZFHEP, DELTAEF1, NIL-2-A, PPCD3, TCF8, Transcription factor 8, ZFHX1A |
Target Sequences: | NM_030751 NP_110378.3 P37275 |
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