Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Gene Name: | zinc finger, C3HC-type containing 1 |
Synonyms: | ZC3HC1, HSPC216, HNIPA, Zinc finger, C3HC type 1, NIPA |
Target Sequences: | NM_016478 NP_057562.3 Q86WB0 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.