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Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene By similarity. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Gene Name: | zinc finger CCCH-type containing 8 |
Synonyms: | ZC3H8, Fliz1, ZC3HDC8 |
Target Sequences: | NM_032494 AAK13496.1 Q8N5P1 |
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