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ZC3H12A / MCPIP1

zinc finger CCCH-type containing 12A

Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.

Gene Name: zinc finger CCCH-type containing 12A
Synonyms: ZC3H12A, DJ423B22.1, MCPIP, Ribonuclease ZC3H12A, MCP induced protein 1, MCP-induced protein 1, MCPIP1, RP3-423B22.1
Target Sequences: NM_025079 NP_079355.2 Q5D1E8

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ZC3H12A / MCPIP1 (4)
No (4)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
ZC3H12A / MCPIP1 Protein - Purified recombinant protein ZC3H12A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
65.5 kDa
20 µg/$1,107
ZC3H12A / MCPIP1 Protein - 12.5% SDS-PAGE of human ZC3H12A stained with Coomassie Blue
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Wheat Germ Extract
GST
92.2 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
65.5 kDa
20 µg/$150
ZC3H12A / MCPIP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
65.5 kDa
100 µg/$494
Viewing 1-4 of 4 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).