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ZC3H12A / MCPIP1
zinc finger CCCH-type containing 12A
Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.
| Gene Name: | zinc finger CCCH-type containing 12A |
| Synonyms: | ZC3H12A, DJ423B22.1, MCPIP, Ribonuclease ZC3H12A, MCP induced protein 1, MCP-induced protein 1, MCPIP1, RP3-423B22.1 |
| Target Sequences: | NM_025079 NP_079355.2 Q5D1E8 |
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