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Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
Gene Name: | Z-DNA binding protein 1 |
Synonyms: | ZBP1, C20orf183, DAI, DJ718J7.3, DLM1, Z-DNA-binding protein 1, DLM-1, Z-DNA binding protein 1 |
Target Sequences: | NM_030776 |
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