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ZAK is a MLK(MAP3K) type protein kinase that mediates the cell cycle signals leading to G2 arrest, possibly by regulating cyclin E expression. ZAK is activated in response to osmotic shock with hyperosmolar media through autophosphorylation. The expression of ZAK is increased by activation of the ERK/MAPK pathway and activates the ERK, JNK/SAPK, p38, and ERK5 pathways. There are two alternatively spliced forms of ZAK, and only the alpha form causes the disruption of actin stress fibers and dramatic morphological changes.
Gene Name: | sterile alpha motif and leucine zipper containing kinase AZK |
Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
Synonyms: | ZAK, HCCS-4, MLTK, MLK-related kinase, MLK7, MLT, MRK, Mlklak, AZK, Mixed lineage kinase 7, PK |
Target Sequences: | AB049733 NP_057737.2 Q9NYL2 |
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