YY1

YY1 transcription factor

Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

YY1 (7)

Publications

No (7)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human YY1 Protein (Recombinant His) - LS-G3072

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Human YY1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75593

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

20 µg/$150

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Human YY1 Protein (Recombinant 6His, C-terminus) (Val221-Gly321) - LS-G140430

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.6 kDa

Price:

10 µg/$317; 50 µg/$524

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Human YY1 Protein (Recombinant 6His, C-terminus) (Val221-Gly321) - LS-G39835

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.6kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Human YY1 Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G60537

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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YY1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100049

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.5 kDa

Price:

100 µg/$494

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Human YY1 Protein (Recombinant GST) (Full Length) - LS-G30923

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

71.1 kDa

Price:

2 µg/$439

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