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YWHAZ / 14-3-3 Zeta belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
Gene Name: | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | YWHAZ, 14-3-3 protein zeta/delta, 14-3-3-zeta, 14-3-3 delta, 14-3-3 protein zeta, 14-3-3 zeta, Phospholipase A2, YWHAD, KCIP-1 |
Target Sequences: | NM_003406 NP_003397.1 P63104 |
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