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Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.
Gene Name: | YOD1 deubiquitinase |
Synonyms: | YOD1, DUBA8, DUBA-8, HIN-7, HsHIN7, OTU domain containing 2, OTUD2, PRO0907, RP11-164O23.1, HIN7, HIV-1-induced protease 7, Ubiquitin thioesterase OTU1 |
Target Sequences: | Q5VVQ6 Q5VVQ6 |
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