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YAP / YAP1

Yes-associated protein 1

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

Gene Name: Yes-associated protein 1
Synonyms: YAP1, 65 kDa Yes-associated protein, YAP, Yes-associated protein beta, Yes-associated protein delta, Yorkie homolog, YAP2, Yes-associated protein 1, Yes-associated protein 2, YKI, YAP65
Target Sequences: NM_006106 NP_006097.2 P46937

Publications (2)

1
A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma. Jung Hyun Jo, Dawoon E Jung, Hee Seung Lee, Soo Been Park, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Sangsook Cho, Si Young Song. International journal of cancer. Journal international du cancer. 2022 November;151:1565-1577. [Full Text Article] [PubMed:35657348] [PMC:PMC9545559]
2
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Feiyang Ma , Pei-Suen Tsou , Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A Hile, Paul W Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L Modlin, John Varga, Lam C Tsoi, Robert Lafyatis, J Michelle Kahlenberg, Allison C Billi, Dinesh Khanna, Johann E Gudjonsson. Nature communications. 2024 January;15:210. [Full Text Article] [PubMed:38172207] [PMC:PMC10764940] Related Antibodies: LS-C331201.

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Proteins (9)
Over-Expression Lysate (4)
Recombinant (5)
YAP / YAP1 (9)
No (9)
6His, N-terminus (1)
6His-B2M, N-terminus (1)
GST, N-terminus (2)
Myc-DDK (Flag) (5)
Human (7)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Yeast (1)
Purified (2)
YAP / YAP1 Protein - 12.5% SDS-PAGE of human YAP1 stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
80.9 kDa
10 µg/$479; 25 µg/$670
YAP / YAP1 Protein
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Yeast
6His, N-terminus
56.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
YAP / YAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
48.6 kDa
100 µg/$710
YAP / YAP1 Protein - Purified recombinant protein YAP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.3 kDa
20 µg/$1,107
YAP / YAP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
YAP / YAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
53.2 kDa
20 µg/$150
YAP / YAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.6 kDa
20 µg/$215
YAP / YAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
53.2 kDa
100 µg/$494
YAP / YAP1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-B2M, N-terminus
68.5 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).