XRCC6 / Ku70

X-ray repair complementing defective repair in Chinese hamster cells 6

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

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Products

ELISA Kits (7)

Type

Cell-Based (2)

Cell-Based Phosphorylation (1)

Sandwich (2)

Sandwich CLIA (2)

Target

XRCC6 / Ku70 (7)

Reactivity

Human (5)

Mouse (5)

Rat (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (4)

Publications

No (7)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Tissue Homogenates (4)

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Human XRCC6 / Ku70 (Sandwich ELISA) ELISA Kit - LS-F4618

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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Mouse/Human XRCC6 / Ku70 (Cell-Based ELISA) ELISA Kit - LS-F2990

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human Phospho-XRCC6 / Ku70 (Ser5) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1150

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat XRCC6 / Ku70 (Cell-Based ELISA) ELISA Kit - LS-F2113

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse XRCC6 / Ku70 (Sandwich ELISA) ELISA Kit - LS-F7950

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$782

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Human XRCC6 / Ku70 (CLIA) ELISA Kit - LS-F26561

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

27.43 - 20000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Tissue Homogenates

Price:

1 Plate/$851

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Mouse XRCC6 / Ku70 (CLIA) ELISA Kit - LS-F26562

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

13.72 - 10000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Tissue Homogenates

Price:

1 Plate/$871

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