XPOT / Exportin-T

exportin, tRNA

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

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Products

Proteins (2)

Type

Recombinant (2)

Target

XPOT / Exportin-T (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human XPOT / Exportin-T Protein (Recombinant GST) (Full Length) - LS-G32588

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

136.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human XPOT / Exportin-T Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61805

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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