XPO1 / CRM1

exportin 1 (CRM1 homolog, yeast)

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

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Antibodies (36)

Proteins (2)

ELISA Kits (1)

Type

Primary (36)

Recombinant (2)

Sandwich (1)

Target

XPO1 / CRM1 (39)

Reactivity

Human (37)

Mouse (16)

Rat (11)

Bat (4)

Bovine (7)

Chicken (4)

Chimpanzee (3)

Dog (7)

Gibbon (6)

Horse (7)

Monkey (7)

Pig (11)

Rabbit (6)

Xenopus (4)

Zebrafish (3)

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Application

IHC (9)

IHC-Fr (1)

IHC-P (7)

WB (29)

Flo (4)

ELISA (7)

ICC (2)

IF (1)

IP (4)

Peptide-ELISA (1)

Host

rabbit (33)

mouse (3)

Product Group

IHCPlus (3)

Isotype

IgG (18)

IgG2b (3)

Clonality

monoclonal mc (3)

polyclonal pc (33)

Format

96-Well Strip Plate (1)

APC (1)

APC Conjugated (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

DY488 Conjugated (1)

DY550 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (18)

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Epitope

aa917-1071 (8)

C-Terminus (4)

aa809-858 (4)

aa1025-C-term (2)

Acetyl-Lys568 (1)

Internal (1)

aa375-425 (1)

aa390-408 (1)

aa817-846 (1)

Publications

No (39)

Sample Type

Cell Lysates (1)

Tissue Homogenates (1)

Tag

GST (1)

His-T7 (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ XPO1 / CRM1 Antibody (aa390-408) LS-B1776

(4.0) Rating

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa390-408) Antibody

Reactivity:

Xenopus, Chicken, Bovine, Bat, Dog, Horse, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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XPO1 / CRM1 Antibody LS-C756643

Antibody:

XPO1 / CRM1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

Flo, ICC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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Human XPO1 / CRM1 Protein (Recombinant His-T7) (aa917-1071) - LS-G24720

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.4 kDa

Price:

10 µg/$271; 50 µg/$377; 100 µg/$602; 200 µg/$752; 1 mg/$1,804; 500 µg/$1,367; 5 mg/$2,762; 2 mg/$1,985

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Human XPO1 / CRM1 Protein (Recombinant GST) (Full Length) - LS-G30915

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

143.55 kDa

Price:

2 µg/$439

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IHC-plus™ XPO1 / CRM1 Antibody (aa1025-C-term) LS-B11039

(4.0) Rating

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa1025-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$460

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XPO1 / CRM1 Antibody (Internal) LS-C387607

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ XPO1 / CRM1 Antibody (aa1025-C-term) LS-B11299

(4.0) Rating

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa1025-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$460

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XPO1 / CRM1 Antibody LS-C500034

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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XPO1 / CRM1 Antibody (Biotin) LS-C500043

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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XPO1 / CRM1 Antibody (FITC) LS-C500033

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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XPO1 / CRM1 Antibody (aa809-858) LS-C80338

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa809-858) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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XPO1 / CRM1 Antibody (aa817-846) LS-C98422

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa817-846) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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XPO1 / CRM1 Antibody LS-C664800

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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Human XPO1 / CRM1 (Sandwich ELISA) ELISA Kit - LS-F9390

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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XPO1 / CRM1 Antibody LS-C661891

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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XPO1 / CRM1 Antibody LS-C829998

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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XPO1 / CRM1 Antibody LS-C490672

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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XPO1 / CRM1 Antibody (aa917-1071) LS-C372920

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa917-1071) Antibody

Reactivity:

Pig, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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XPO1 / CRM1 Antibody LS-C803618

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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XPO1 / CRM1 Antibody (DY550) LS-C756646

Antibody:

XPO1 / CRM1 Mouse anti-Human Monoclonal (DY550) Antibody

Reactivity:

Human

Applications:

Flo

Format:

DY550 Conjugated

Price:

100 µg/$571

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XPO1 / CRM1 Antibody (DY488) LS-C756644

Antibody:

XPO1 / CRM1 Mouse anti-Human Monoclonal (DY488) Antibody

Reactivity:

Human

Applications:

Flo

Format:

DY488 Conjugated

Price:

100 µg/$571

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XPO1 / CRM1 Antibody (Acetyl-Lys568) LS-C413271

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (Acetyl-Lys568) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$341

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XPO1 / CRM1 Antibody (C-Terminus) LS-C110522

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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XPO1 / CRM1 Antibody LS-C330908

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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XPO1 / CRM1 Antibody (aa375-425) LS-C287376

Antibody:

XPO1 / CRM1 Rabbit anti-Human Polyclonal (aa375-425) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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