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XBP1

X-box binding protein 1

XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

Gene Name: X-box binding protein 1
Synonyms: XBP1, X-box binding protein 1, X-box-binding protein 1, XBP2, TREB5, XBP-1
Target Sequences: NM_005080 NP_005071.2 P17861

Publications (5)

1
2-Methoxyestradiol at low dose induces differentiation of myeloma cells. Hou J, Xiong H, Gao W, Jiang H. Leukemia research. 2005 29:1059-67. [PubMed:16038732]
2
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Thuerauf DJ, Marcinko M, Gude N, Rubio M, Sussman MA, Glembotski CC. Circulation research. 2006 99:275-82. [PubMed:16794188]
3
Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol. Zhou X, Jiang H, Hou J. Leukemia research. 2007 31:1259-65. [PubMed:17257674]
4
Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Kim KM, Pae HO, Zheng M, Park R, Kim YM, Chung HT. Circulation research. 2007 101:919-27. [PubMed:17823375]
5
Physical Exercise Reduces Cytotoxicity and Up-Regulates Nrf2 and UPR Expression in Circulating Cells of Peripheral Artery Disease Patients: An Hypoxic Adaptation?. Anna Maria Fratta Pasini, Chiara Stranieri, Anna Maria Rigoni, Sergio De Marchi, Denise Peserico, Chiara Mozzini, Luciano Cominacini, Ulisse Garbin. Journal of atherosclerosis and thrombosis. 2018 September;25:808-820. [Full Text Article] [PubMed:29540636] [PMC:PMC6143780]
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ELISA Kits (12)
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XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
XBP1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
13.7 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$851
XBP1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
13.7 - 10000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$871
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$748
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
XBP1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
XBP1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
XBP1 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).