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Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
Gene Name: | WD repeat and SOCS box containing 1 |
Synonyms: | WSB1, WSB-1, SWIP1 |
Target Sequences: | NM_015626 NP_056441.6 Q9Y6I7 |
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