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Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Gene Name: | WD repeat domain 34 |
Synonyms: | WDR34, BA216B9.3, RP11-216B9.5, WD repeat domain 34 |
Target Sequences: | Q96EX3 Q96EX3 |
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