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WC1 / ATP7B
ATPase, Cu++ transporting, beta polypeptide
WC1 / ATP7B is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
| Gene Name: | ATPase, Cu++ transporting, beta polypeptide |
| Family/Subfamily: | Transporter , ATPase - P type, type IB |
| Synonyms: | ATP7B, Copper-transporting ATPase 2, WC1, Wilson disease, PWD, WD, Copper pump 2, WND |
| Target Sequences: | NM_000053 NP_000044.2 P35670 |
Publications (3)
1
NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Guo Y, Nyasae L, Braiterman LT, Hubbard AL. American journal of physiology. Gastrointestinal and liver physiology. 2005 289:G904-16. (WB; Human, Rat)
[PubMed:15994426]
2
Characterization of Sandwich-Cultured Hepatocytes as an In Vitro Model to Assess the Hepatobiliary Disposition of Copper. John H. Ansede, Matthew R. Wright, Robert L. St. Claire III,. Drug metabolism and disposition: the biological fate of chemicals. 2009 37:969-76. (WB; Dog, Human, Rat)
[Full Text Article]
[PubMed:19237514]
3
Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Chen HH, Yan JJ, Chen WC, Kuo MT, Lai YH, Lai WW, Liu HS, Su WC. Lung cancer (Amsterdam, Netherlands). 2012 Feb;75:228-34. [Full Text Article]
[PubMed:21788094]
[PMC:PMC3319119]
Related Antibodies: LS-B2302.
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WC1 / ATP7B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (Biotin) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Biotin Conjugated
100 µg/$475
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (FITC) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
FITC Conjugated
100 µg/$472
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (Atto 390) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 390 Conjugated
100 µg/$479
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (Atto 488) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 488 Conjugated
100 µg/$479
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (Atto 594) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Atto 594 Conjugated
100 µg/$479
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (APC) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
APC Conjugated
100 µg/$478
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (RPE) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
RPE Conjugated
100 µg/$477
WC1 / ATP7B Mouse anti-Human Monoclonal (aa3-21) (PerCP) (S62-29) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
PerCP Conjugated
100 µg/$478
WC1 / ATP7B Rabbit anti-Human Polyclonal (aa161-210) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
WC1 / ATP7B Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
WC1 / ATP7B Rabbit anti-Human Polyclonal (aa1166-1465) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
WC1 / ATP7B Mouse anti-Human Monoclonal (3E10) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
293T Cells
Myc-DDK (Flag)
157.1 kDa
20 µg/$215
WC1 / ATP7B Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
0.1 ml/$386
WC1 / ATP7B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
WC1 / ATP7B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC
Unconjugated
50 µg/$305; 100 µg/$357
HEK 293 Cells
Myc-DDK (Flag)
157.1 kDa
20 µg/$1,107
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$748
HEK 293 Cells
Myc-DDK (Flag)
157.1 kDa
100 µg/$710
WC1 / ATP7B Rabbit anti-Human Polyclonal (130-210 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
WC1 / ATP7B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
WC1 / ATP7B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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