Corporate Headquarters
Vector Laboratories, Inc.
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United States
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Gene Name: | V-set domain containing T cell activation inhibitor 1 |
Synonyms: | VTCN1, B7 superfamily member 1, B7 Superfamily, member 1, B7h.5, B7S1, B7H4, PRO1291, VCTN1, RP11-229A19.4, B7 family member, H4, B7-H4, B7X, Protein B7S1 |
Target Sequences: | NM_024626 NP_078902.2 Q7Z7D3 |
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