VR1 / TRPV1

transient receptor potential cation channel, subfamily V, member 1

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.

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Antibodies (49)

ELISA Kits (11)

Proteins (10)

Type

Custom (3)

Over-Expression Lysate (8)

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Target

VR1 / TRPV1 (70)

Reactivity

Human (43)

Mouse (26)

Rat (29)

Chicken (1)

Dog (1)

Guinea pig (2)

Primate (5)

Application

IHC (18)

IHC-Fr (3)

IHC-P (8)

WB (29)

ELISA (11)

ICC (10)

IF (9)

IP (2)

Peptide-ELISA (1)

Host

rabbit (44)

mouse (1)

chicken (1)

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rabbit-new zealand white (1)

Product Group

PathPlus Neuro (2)

Isotype

IgG (16)

IgG2a,k (1)

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monoclonal mc (1)

polyclonal pc (48)

Clone

1A8 (1)

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12 x 8-Well Microstrips (1)

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96-Well Strip Plate (9)

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aa817-838 (1)

Publications

No (70)

Sample Type

Cell Lysates (3)

Plasma (5)

Serum (5)

Tissue Homogenates (6)

Tag

GST, N-terminus (1)

His, N-terminus (1)

Myc-DDK (Flag) (8)

Species

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Source

293T Cells (4)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

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PathPlus™ VR1 / TRPV1 Antibody (Internal) LS-A9670

Neuroscience

Fast Shipping

(5.0) Rating

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Guinea pig, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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PathPlus™ VR1 / TRPV1 Antibody LS-B12677

Neuroscience

(5.0) Rating

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$460

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VR1 / TRPV1 Antibody (DY488) LS-C180119

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (DY488) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P

Format:

DY488 Conjugated

Price:

0.1 ml/$416

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VR1 / TRPV1 Antibody (DY650) LS-C180118

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (DY650) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P

Format:

DY650 Conjugated

Price:

0.1 ml/$416

• Unconjugated
• DY488
• DY650

• Unconjugated
• DY488
• DY650

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VR1 / TRPV1 Antibody LS-C150735

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Primate, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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VR1 / TRPV1 Antibody (Biotin) LS-C181938

Antibody:

VR1 / TRPV1 Rabbit anti-Rat Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Rat, Primate, Human

Applications:

ICC, IF, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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VR1 / TRPV1 Antibody (N-Terminus) LS-C172124

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

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VR1 / TRPV1 Antibody (N-Terminus, Magnetic beads) LS-C172125

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

• Unconjugated
• Magnetic beads

• Unconjugated
• Magnetic beads

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VR1 / TRPV1 Antibody (aa1-153, PE) LS-C727549

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa1-153) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

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VR1 / TRPV1 Antibody (aa124-153) LS-C160237

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa124-153) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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VR1 / TRPV1 Antibody (clone 1A8) LS-C139103

Antibody:

VR1 / TRPV1 Mouse anti-Human Monoclonal (1A8) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human VR1 / TRPV1 (Sandwich ELISA) ELISA Kit - LS-F7693

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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Human VR1 / TRPV1 (Sandwich ELISA) ELISA Kit - LS-F12857

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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VR1 / TRPV1 Antibody (C-Terminus) LS-C21195

Antibody:

VR1 / TRPV1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody

Reactivity:

Rat

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$832

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VR1 / TRPV1 Antibody (aa608-621) LS-C77695

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (aa608-621) Antibody

Reactivity:

Guinea pig, Human

Applications:

IHC

Format:

Unconjugated

Price:

100 µl/$688

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VR1 / TRPV1 Antibody (aa531-541) LS-C77694

Antibody:

VR1 / TRPV1 Rabbit anti-Mouse Polyclonal (aa531-541) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC-Fr

Format:

Unconjugated

Price:

100 µl/$614

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Human VR1 / TRPV1 Protein (Recombinant His, N-terminus) (aa1-153) - LS-G25654

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.4 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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VR1 / TRPV1 Antibody LS-C501373

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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VR1 / TRPV1 Antibody LS-C827828

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$376

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VR1 / TRPV1 Antibody (N-Terminus) LS-C353806

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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Mouse VR1 / TRPV1 (Sandwich ELISA) ELISA Kit - LS-F7453

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

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Rat VR1 / TRPV1 (Sandwich ELISA) ELISA Kit - LS-F36019

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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VR1 / TRPV1 Antibody LS-C829228

Antibody:

VR1 / TRPV1 Chicken anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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VR1 / TRPV1 Antibody LS-C410098

Antibody:

VR1 / TRPV1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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VR1 / TRPV1 Antibody (aa817-838) LS-C21202

Antibody:

VR1 / TRPV1 Guinea pig anti-Rat Polyclonal (aa817-838) Antibody

Reactivity:

Rat

Applications:

IHC

Format:

Unconjugated

Price:

50 µl/$508

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