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May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.
Gene Name: | vacuolar protein sorting 39 homolog (S. cerevisiae) |
Synonyms: | VPS39, HVam6p, KIAA0770, TRAP1-like protein, Vam6/Vps39-like protein, VAM6, TLP |
Target Sequences: | Q96JC1 Q96JC1 |
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