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VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

VPS37A belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

Gene Name: vacuolar protein sorting 37 homolog A (S. cerevisiae)
Synonyms: VPS37A, HCRP1, HVps37A, Vacuolar protein sorting 37A, ESCRT-I complex subunit VPS37A, PQBP2, SPG53
Target Sequences: AAH67754.1 Q8NEZ2

Publications (1)

1
MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Yoon S, Kovalenko A, Bogdanov K, Wallach D. Immunity. 2017 July;47:51-65. (Human) [Full Text Article] [PubMed:28666573]

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VPS37A ELISA Kit
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).