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VPREB1 / CD179A belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants.
Gene Name: | pre-B lymphocyte 1 |
Synonyms: | VPREB1, CD179a, Immunoglobulin iota chain, IGI, Protein VPreB1, VPREB, V(pre)B protein, CD179a antigen, IGVPB, Pre-B lymphocyte 1, VpreB protein |
Target Sequences: | NM_007128 NP_009059.1 P12018 |
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