Vitamin D Receptor / VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

The vitamin D receptor, a NR1 Thyroid Hormone-Like Receptor, is activated by calcitriol, the active hormonal form of vitamin D. The activated receptor binds DNA at a specific vitamin D-responsive element and promotes transcription of vitamin D target genes such as osteocalcin, the most abundant noncollagenous protein in bone. The vitamin D receptor affects growth, bone formation, and female reproduction. For example, this receptor modulates the growth and differentiation of keratinocytes and mediates the beneficial effects of vitamin D on psoriatic skin. It also inhibits hormone secretion by and proliferation of parathyroid cells. The vitamin D receptor functions either as a homodimer or as a heterodimer of vitamin D and retinoid acid X receptor subunits. Inactivation of the receptor leads to hypocalcemia and Rickets-alopecia syndrome. Recently, the vitamin D receptor has been shown to function as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. An alternatively spliced vitamin D receptor that has an altered ligand-binding domain has been isolated from rats.

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Products

Proteins (14)

Type

Over-Expression Lysate (4)

Recombinant (10)

Target

Vitamin D Receptor / VDR (14)

Publications

No (14)

Tag

GST (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (2)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (10)

Mouse (2)

Source

293T Cells (2)

Baculovirus (2)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (3)

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Human Vitamin D Receptor / VDR Protein (Recombinant GST) (Full Length) - LS-G30872

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.71 kDa

Price:

10 µg/$479; 25 µg/$670

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Human Vitamin D Receptor / VDR Protein (Recombinant GST, N-terminus) (aa318-427) - LS-G60506

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Vitamin D Receptor / VDR Protein (Recombinant His) (Met1-Ser427) - LS-G98011

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50 kDa

Price:

50 µg/$721

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Mouse Vitamin D Receptor / VDR Protein (Recombinant His) (Met1-Ser422) - LS-G98304

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.2 kDa

Price:

100 µg/$843

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Human Vitamin D Receptor / VDR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67331

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$1,107

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Human Vitamin D Receptor / VDR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67332

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$1,107

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Vitamin D Receptor / VDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121280

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

100 µg/$710

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Human Vitamin D Receptor / VDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79556

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$215

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Human Vitamin D Receptor / VDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79557

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$150

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Human Vitamin D Receptor / VDR Protein (Recombinant His) (aa21-96) - LS-G140992

Source:

E. coli

Sequence Length:

75 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

8.36 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Vitamin D Receptor / VDR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123230

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

100 µg/$494

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Human Vitamin D Receptor / VDR Protein (Recombinant His, N-Terminal) - LS-G132593

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20kDa

Price:

10 µg/$335; 50 µg/$782; 200 µg/$1,404; 100 µg/$1,190; 1 mg/$2,697; 500 µg/$2,192; 5 mg/$5,461; 2 mg/$2,913

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Human Vitamin D Receptor / VDR Protein (Recombinant His, N-Terminal) (Met272-Ser427) - LS-G132648

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20kDa

Price:

10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse Vitamin D Receptor / VDR Protein (Recombinant His-T7) (aa266-422) - LS-G12219

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.8 kDa

Price:

10 µg/$289; 50 µg/$490; 100 µg/$782; 200 µg/$977; 1 mg/$2,114; 500 µg/$1,640; 5 mg/$3,417; 2 mg/$2,304

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