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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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VHL / Von Hippel Lindau
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
| Gene Name: | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
| Synonyms: | VHL, Elongin binding protein, HRCA1, RCA1, VHL1, Von Hippel-Lindau syndrome, Protein G7, PVHL |
| Target Sequences: | NM_000551 NP_000542.1 P40337 |
Publications (2)
1
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH. Cancer research. 2006 66:3567-75.
[PubMed:16585181]
2
MCM proteins are negative regulators of hypoxia-inducible factor 1. Hubbi ME, Luo W, Baek JH, Semenza GL. Molecular cell. 2011 42:700-12. (WB, IP; Human)
[PubMed:21658608]
[PMC:PMC3131976]
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Antibodies
(47)
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(47)
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VHL / Von Hippel Lindau
(47)
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Human
(39)
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(20)
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(25)
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(4)
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(3)
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(1)
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(3)
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(1)
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(34)
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(38)
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(17)
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(2)
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monoclonal mc
(7)
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(40)
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(2)
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(4)
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(1)
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(35)
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(8)
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(4)
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(3)
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(2)
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(1)
aa1-213
(1)
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(1)
aa181-210
(1)
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(1)
Publications
No
(47)
VHL / Von Hippel Lindau Goat anti-Human Polyclonal (aa167-179) Antibody
Rabbit, Mouse, Dog, Rat, Bat, Human, Monkey
ELISA, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa43-71) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$393
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (OTI1E1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (Carrier-free) (OTI1E1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa181-210) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
VHL / Von Hippel Lindau Goat anti-Human Polyclonal (Internal Region) (Biotin) Antibody
Mouse, Rat, Human
ELISA, Peptide-ELISA, WB
Biotin Conjugated
100 µg/$503
![VHL / Von Hippel Lindau Antibody - Immunofluorescence of monoclonal antibody to VHL on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/vhl-von-hippel-lindau-antibody-clone-1g12-ls-c198428/146953_4997012.jpg)
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (1G12) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$341
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (AT82B10) Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal (ABT-PVHL) Antibody
Human
IHC
Unconjugated
50 µl/$268; 100 µl/$316
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (10-90 aa) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µl/$334; 100 µl/$397
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (Ab-68) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µg/$357
VHL / Von Hippel Lindau Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$586
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (pSer68) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$854
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa43-71) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$508
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal (aa43-71) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$697
VHL / Von Hippel Lindau Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
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product results
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