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Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Gene Name: | vascular endothelial growth factor C |
Family/Subfamily: | PDGF , not assigned-PDGF |
Synonyms: | VEGFC, Flt4-L, FLT4 ligand DHM, VEGF-C, VRP, Flt4 ligand |
Target Sequences: | NM_005429 NP_005420.1 P49767 |
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