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Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Gene Name: | voltage-dependent anion channel 1 |
Family/Subfamily: | Ion Channel , VDAC porin |
Synonyms: | VDAC1, HVDAC1, Plasmalemmal porin, Porin 31HM, PORIN, PORIN-31-HL, Vdac5, VDAC, Mitochondrial porin, Porin 31HL, VDAC-1 |
Target Sequences: | NM_003374 NP_003365.1 P21796 |
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