VAV3

vav 3 guanine nucleotide exchange factor

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

VAV3 (8)

Publications

No (8)

Tag

His (2)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

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Human VAV3 Protein (Recombinant His) (aa183-380) - LS-G15587

Source:

E. coli

Tag:

His

Molecular Weight:

24.7 kDa

Price:

10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988

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Human VAV3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70550

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.6 kDa

Price:

20 µg/$1,107

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Human VAV3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70551

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$1,107

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Human VAV3 Protein (Recombinant His) (aa398-583) - LS-G15599

Source:

E. coli

Tag:

His

Molecular Weight:

23.2 kDa

Price:

10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988

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Human VAV3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87419

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.6 kDa

Price:

20 µg/$215

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Human VAV3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87418

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$150

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VAV3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120142

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

100 µg/$494

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VAV3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115523

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

97.6 kDa

Price:

100 µg/$710

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