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UTS2 / Urotensin II is a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.
Gene Name: | urotensin 2 |
Synonyms: | UTS2, Urotensin 2, U-II, Urotensin II, PRO1068, UII, Urotensin-2 |
Target Sequences: | NM_006786 NP_006777.1 O95399 |
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