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The utrophin protein accumulates at neuromuscular synapses and myotendinous junctions. Similarly to dystrophin, utrophin associates with the sarcolemmal dystroglycan complex and anchors the cytoskeleton protein to agrin and laminin in the plasma membrane. Duchenne Muscular Dystrophy (DMD), a disease caused by mutations of the dystrophin gene, is a severe progressive muscle-degenerative disorder that results in premature death. Because utrophin is up-regulated and can compensate for the absence of functional dystrophin in the mouse model for DMD, this gene may prove a useful therapeutic alternative in the treatment of the disease.
Gene Name: | Utrophin |
Synonyms: | UTRN |
Target Sequences: | NM_007124 NP_009055.2 P46939 |
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