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Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Gene Name: | ubiquitin specific peptidase 6 (Tre-2 oncogene) |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP6, Proto-oncogene TRE-2, Tre-2, Tre-2 oncogene, Ubiquitin specific protease 6, Ubiquitin thioesterase 6, Deubiquitinating enzyme 6, HRP1, Hyperpolymorphic gene 1, TBC1D3 and USP32 fusion, TRE2, Ubiquitin thiolesterase 6, USP6-short |
Target Sequences: | NM_004505 NP_004496.2 P35125 |
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